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4.3 Challenges in the application of EVs in DOP The most important factors for EVS are how to stabilize production on a large scale and have low load efficiency (118)

STK38-deficient colorectal tumour xenografts exhibited resistance to necroptosis-based therapies in vivo, underscoring the importance of the STK38-RIPK1 axis in regulating tumour cell death and influencing the therapeutic response in colorectal cancer