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Axonal degeneration as a therapeutic target in the CNS

Side effects are rare and typically mild, sometimes including transient changes in sleep patterns as circadian rhythms adjust

The present review aims to summarize the available evidence regarding the key regulators involved in the modulation of the somatotroph axis in humans, presenting detailed molecular insights on the signaling cascades at play

Disclosure of interest: Nothing to disclose Poster session I - DIAGNOSIS / ETIOLOGY 04.00 - DIAGNOSIS / ETIOLOGY - 04.01 - DIAGNOSIS/INVESTIGATION OF STROKE ETIOLOGY P355 - ESOC25-189 VESSEL WALL ENHANCEMENT IN TERMINAL OF INTERNAL CAROTID ARTERY WAS DECREASED AFTER DIRECT BYPASS SURGERY FOR MOYAMOYA DISEASE Daizo Ishii 1 , Takeshi Hara 1 , Masashi Kuwabara 1 , Hiroshi Kondo 1 , Shinji Kume 2 , Nobutaka Horie 1 1 Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan, 2 Hiroshima University Hospital, Hiroshima, Japan Background and Aims: Intracranial vessel wall enhancement (VWE) on MR imaging is associated with progression and poor outcome in moyamoya disease (MMD)