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25 Patients diagnosed with vitamin B 12 deficiency whose history and physical examination do not suggest an obvious dietary or malabsorptive etiology should be tested for pernicious anemia with anti-intrinsic factor antibodies (positive predictive value = 95%), particularly if other autoimmune disorders are present

It stimulates the pituitary gland to produce and secrete endogenous growth hormone through natural pulsatile patterns, distinguishing it mechanistically from exogenous GH administration

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