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Supplementation strategies vary depending on the underlying cause of deficiency or risk factors: Oral supplements (typically 25-2000 micrograms daily) are suitable for individuals with adequate intrinsic factor production but insufficient dietary intake Sublingual or buccal preparations have no proven superiority over standard oral tablets at equivalent doses Intramuscular injections (usually 1000 micrograms of hydroxocobalamin) are the preferred treatment for pernicious anaemia and severe malabsorption

Following successful model induction, the Uricase and RBC@SeMSN@Uri groups received intravenous injections of 10 mg/kg of Uricase or RBC@SeMSN@Uri at 0 h

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Surgical technique and cocktail treatment The detailed procedure is in accordance with that reported in previous studies [4, 6, 8]