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Description

Epigenetic regulation of hypoxia inducible factor in diseases and therapeutics

BBB breakdown is well characterized in AD, Parkinsons disease (PD), Amyotrophic lateral sclerosis (ALS), Multiple Sclerosis (MS), and Huntingtons disease (HD)

After rearranging the expression defining K a , and putting pH = -log 10 (H + ), one obtains pH = pK a + (A - ) / (HA) and further pH - pK a = log(A - ) / (HA) Then, a solution with 50% dissociation has pH equal to the pK a of the acid