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Premature ovarian insufficiency and long-term health consequences

However, here are some general guidelines: For individuals with a B12 deficiency, a common protocol may involve a daily dosage of 1,000 mcg for one week, followed by the same dosage once weekly, and then once per month after addressing the deficiency

Many older adults are at risk for these side effects

Other differences between these studies were the choice of ovarian insult, with our study using doxorubicin and cisplatin, rather than cyclophosphamide and -irradiation, and the choice of timepoint, with our studies conducted at 2 months post-chemotherapy, rather than 5 days