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Provides potent antioxidant protection from oxidative stress and environmental damage

Phase I/II trials for various cancers (NCT04480502, NCT02465285) are evaluating liposomal curcumin in combination with radiotherapy or chemotherapy, with preliminary data indicating enhanced tumor suppression and reduced toxicity [24]

Zeisel 1 , (1)Cancer Research Center of Lyon (CRCL), Umr Inserm 1052 Cnrs 5286 Mixte Clb, Universit Lyon 1 (UCBL1), (2)Department of Hepatology, Croix Rousse Hospital, Hospices Civils De Lyon, France Background: Enhancer of Zeste Homolog 2 (Ezh2) is frequently upregulated in hepatocellular carcinoma (HCC) tissues and increased Ezh2 expression correlates with HCC aggressiveness and/or poor prognosis

Among the more notable nonenzymatic varieties include metal-binding proteins, glutathione (GSH), uric acid, melatonin, and lipoic acid as well as bilirubin and polyamines.1,4 Nonenzymatic antioxidants work closely with enzymatic counterparts, which include superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione reductase (GR), thioredoxin, and peroxiredoxins, among others.4 Both enzymatic and nonenzymatic antioxidants may require nutrients for synthesis and regeneration or as enzyme cofactors