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Studies have compared MT-II with PT-141 and MC4R-selective agonists to dissect MC3R versus MC4R contributions to pro-sexual effects and to characterise the role of MC1R activation in modifying central sexual behaviour biology

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In addition, PT-141 has also been tested in men, particularly in the form of intranasal spray, and the available studies suggest that the peptide is also highly effective for improving sexual desire and erectile function in males [6]