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Melatonin enhances antioxidative enzyme gene expression (CAT, GPx, SOD), prevents their UVR-induced depletion, and protects against the formation of DNA damage (8-hydroxy-2-deoxyguanosine) in ex vivo human skin

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VDAC2/3 knockdown inhibits erastin-induced ferroptosis, and erastin directly binds VDAC2 (117)