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Intercellular adhesion molecule 1 ( Icam1 ) mediates the adhesion and transmigration of leukocytes across the endothelium to promote inflammation in the vasculature

[5] On May 5, 2010 the Italian Medicines Agency (AIFA - Agenzia Italiana del Farmaco) became the first governmental health organization ever (even before the drug received approval in Europe) to authorize afamelanotide as a medicine for therapeutic treatment of Italian citizens to reduce painful photosensitivity stemming from the orphan disease erythropoietic protoporphyria (EPP)

Harach T, Marungruang N, Duthilleul N et al (2017) Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota

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