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This may provide some protective effect, though it should not be considered a complete offset

Hepatocyte growth factor regulates macrophage transition to the M2 phenotype and promotes murine skeletal muscle regeneration

Continued progressive improvement

It is an under-recognized sign of megaloblastic anemia and should always be looked for in the setting of pallor." Reference: Pannu AK: Knuckle pigmentation and vitamin B12 deficiency