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Dose timing flexibility exists as long as cold-chain integrity is maintained

In Phase 2 trials, these effects were most pronounced during dose escalation phases and tended to diminish over time

234 The nonsteroidal anti-inflammatory drug diclofenac can significantly reduce the protein expression level of NF-B p65 and the phosphorylation level of IB-, effectively protecting the structure and function of the intestinal barrier by suppressing the iNOS/NF-B pathway and activating the expression of HO-1