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337,338 It has been shown to prevent the progression of age-dependent intervertebral disc degeneration, 339 reduce intestinal SnCs and excessive inflammation in aged mice, 340 and effectively induce apoptosis, thereby eliminating SnCs and the SASP burden in adipose tissue

The corresponding genes are: F41E6.5 ( gox-1 ), encoding the ortholog of the human glycolate oxidase (HAO-1)

In addition to VEGFR-2 and VEGFR-3, neuropilins, specifically neuropilin-1 (NRP1) and NRP2, expressed on tip cells, act as coreceptors for VEGF and enhance their function [57]