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Such behavioral deficits in A53T mice were accompanied by the presence of elevated -synuclein monomers and aggregates (Supplemental Figure 1J) and a remarkable loss of dopaminergic neurons in the substantia nigra, as indicated by tyrosine hydroxylase (TH) staining (Figure 1C)

UT Southwestern physicians in more than 80 specialties care for more than 143,000 hospitalized patients, attend to more than 470,000 emergency room cases, and oversee nearly 5.3 million outpatient visits a year.

Thus, cellular metabolic pathways and immunological responses (such as the production of important transcription factors) are closely regulated in both directions, either preserving immune homeostasis or aiding in the pathophysiology of illness

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