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Conflict of interest AS, YS, AG, EC, NT, and JO were employed by Process Research and Development, Merck & Co., Inc

5.1 Passive targeting strategies Polymeric nanoscale carriers (10200 nm) passively accumulate in tumors via the enhanced permeability and retention (EPR) effect due to leaky vasculature and impaired lymphatic drainage

INTRODUCTION Pancreatic cancer is a lethal malignancy with a five-year survival rate of 3%-5%[1,2]

The specimens were embedded in paraffin blocks, 5-m slices were obtained from them, mounted on slides, deparaffinated with xylene, and rehydrated with ethanol