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The accumulated crystals can be further enlarged and self-aggregated, leading to the stone formation (Figure 1)

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Sim J, Cowburn AS, Palazon A, Madhu B, Tyrakis PA, Macas D, Bargiela DM, Pietsch S, Gralla M, Evans CE (2018) The factor inhibiting HIF asparaginyl hydroxylase regulates oxidative metabolism and accelerates metabolic adaptation to hypoxia

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