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The increased tissue biopterin levels were predominantly comprised of BH4, but analogous to the in vitro experiments, the increase in tissue BH4 was markedly inhibited by pretreatment with 10 mg/kg methotrexate before administration of either sepiapterin, BH2 or BH4

Oxidative Medicine and Cellular Longevity 1

However, it is unknown whether the same effect would be observed in older adults with moderate milk intake or whether consuming more than 3 cups/day would provide added benefit

26 Schauss speculates that this may have been due to a conflict of interest, claiming that the sister of one of the NIH reviewers owned and operated a large addiction center in New Orleans, Louisiana at the time (A