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Interestingly, the loop connecting helices 2 and 3 ( 208- GTSSTG 213 ) of SemDAPH is stabilised in the complex and can now be modelled

Additionally, nitrosamines (e.g., NDMA) generate alkylating intermediates that damage the genome through DNA adducts such as m6G, inducing abnormal DNA methylation and increasing the risk of malignant transformation in bladder cancer cells (Anderson et al., 1996