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In contrast to apoptosis and necrosis, ferroptosis is characterized by extensive damage to membrane lipids and is intricately associated with mitochondrial metabolic dysfunctions (38)

Of note, many of the flavonoids contain a catechol group and can be easily oxidized by tyrosinase, as revealed earlier for quercetin which functioned as a tyrosinase substrate 87,88

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doi: 10.1161/CIRCRESAHA.117.311401 31 CaoSSKaufmanRJ