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Figure 1 Surviving fractions of CL1-0 and CL1-5 cells after treatment with 2-, 5-, and 10-Gy radiation

To conclude, the cell membrane is not only a vital site for ROS generation but also serves as a crucial platform for the transmission of redox signals

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Conclusions and outlook In their 1979 review Ascorbic Acid and Cancer: A Review [242], Linus Pauling and colleagues expressed their hopes that properly designed controlled trials would soon be conducted to confirm or refute their clinical findings, and that if confirmed, ascorbate will soon become an essential part of all practical cancer treatment and cancer prevention regimens