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Stimulation of macrophages with HGF results in differentiation of M1 macrophages to M2 subtypes (64), underscoring the functional relevance of HGF/Met axis in the antitumor immune response

ROS-associated tumor immunity in ICI therapy ICIs activate the immune systems attack on tumors by inhibiting immunosuppressive molecules on the surface of tumor cells, such as PD-1, PD-L1, and Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4)

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Approach Standard pulse Typical Range 100-200 mcg Frequency Once daily SC Notes Common community research range, based partly on kisspeptin-54 trial data