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The pulsatile nature of this release is clinically significant: it mimics endogenous GH secretion rhythms, preserving downstream IGF-1 production, protein synthesis, and fat oxidation without the sustained GH elevation that can impair insulin sensitivity

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In the SURMOUNT-1 trial, tirzepatide also produced substantial weight reduction compared with placebo in adults with obesity or overweight with weight-related complications

Notably, while HK2 knockdown sensitized cells to TNF alone-induced death and increased the activation of RIPK1 in WT RIPK1-reconstituted cells, HK2 knockdown did not induce cell death and RIPK1 activation in RIPK1 S32E-reconstituted cells treated with TNF alone (Fig