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Pharmacokinetics & drug-delivery barriers Many ferroptosis inhibitors are lipophilic small molecules that suffer from rapid metabolism and clearance, yielding subtherapeutic bioavailability in cardiac tissue

In addition, plateau pulmonary hypertension and increased pulmonary blood flow resistance will also lead to increased right heart load and right ventricular myocardial hypertrophy, ultimately leading to irreversible damage to the myocardium and cardiac conduction system [74, 76]

Geographically, Latin America and the Caribbean had the highest proportion of DR-related blindness (6.9%), whereas North Africa and the Middle East reported the highest rates of MSVI (2.1%)

Kempuraj D, Thangavel R, Natteru PA, Selvakumar GP, Saeed D, Zahoor H, Zaheer S, Iyer SS, Zaheer A (2016) Neuroinflammation Induces Neurodegeneration