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Potential Role of Chronic Physical Exercise on Redox System Modulation: Implications on Vitiligo Development Vitiligo Patients have an associated high rate of inflammatory comorbidities such as MetS and cardiovascular diseases ( Initially, acute PE (mainly the aerobic-type) was believed to be a bad approach once it increases 20 times oxygen consumption and sharply increases ROS and reactive nitrogen species (RNS) production (Vargas-Mendoza et al., 2019)

Amifostine at a dose of 25 mg/kg significantly reduced oxaliplatin-induced c-Fos, nitrotyrosine, and activating transcription factor 3 (ATF3) expression, showing protective effects against nitrosative stress, neuronal hyperactivation and neuronal damage to dorsal root ganglion neurons in mice [147]

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