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Postinjury inflammation and organ dysfunction

Eight-week NAC treatment did not reduce cocaine use in patients with CUD, however, it was shown that NAC prevented cocaine relapse rather than promoted initial drug-abstinence [82]

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If the rate of absorption is rapid relative to distribution (this is always true for rapid intravenous administration), the concentration of drug in plasma that results from an appropriate loading dosecalculated using the apparent volume of distributioncan initially be considerably higher than desired