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This effect is likely due to indirect stimulation of the calcium channel on the pancreatic islet cells where insulin is made and stored

Elsayegh D et al

In this respect, SetCys uncovers an unusual mode of reactivity for Cys and provides a useful means for accessing complex protein scaffolds as illustrated by the total one-pot synthesis of biologically active backbone-cyclized variants of the hepatocyte growth factor (HGF) kringle 1 (K1) domain