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Mechanistically, Hedgehog binding to the transmembrane protein patched (PTC) induces the activation of smoothened (SMO), which stimulates the expression of downstream genes such as Ccnd1 via zinc finger transcription (GLI) factors

Virus-induced hyper-inflammation with complement activation in kidney tissue could inflict focal segmental glomerulo-sclerosis with glomerular involution and lead to AKI 138