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Although initial studies indicate that treatments such as iron chelators and lipid peroxidation inhibitors may have cardioprotective effects, their long-term efficacy and safety profiles have not been comprehensively evaluated in clinical trials, leaving significant room for further investigation (Yang T

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Blood J Am Soc Hematol 101(8):30143020 Gao N et al (2002) Vanadate-induced expression of hypoxia-inducible factor 1 and vascular endothelial growth factor through phosphatidylinositol 3-kinase/Akt pathway and reactive oxygen species