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Ferroptosis is characterized morphologically by decreased mitochondrial volume, denser mitochondrial bilayer membranes, and often diminished or absent mitochondrial cristae yet with an intact cell membrane, normal-sized nucleus, and no chromatin condensation ( Figure 1 Ferroptosis inducers are categorized into four groups

Endosomes release Fe 2+ into the cytoplasmic labile iron pool (LIP), which requires DMT1/Solute Carrier Family 11 Member 2 (SLC11A2) regulation (Zhou et al., 2020) (Figure 3)