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Fifteen healthy seedlings were placed in a pot containing modified Hoagland nutrient solution, as described earlier by Por et al (2011), and they were grown for 10 d in a controlled environment: 200 mol m 2 s 1 photosynthetic photon flux density (PSI, Drsov, Czech Republic), 12/12-h light/dark period (light phase starting from 06:00 until 18:00 h and 12 h dark period during the remaining daytime), 24/22 C day/night temperatures, and 55%60% relative humidity (Czkus et al., 2021)

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By providing an unmethylated blend of adenosylcobalamin and hydroxycobalamin, this supplement supports the underlying methylation cycleensuring the HNMT enzyme has what it needs to break down histaminewithout forcing the aggressive, rapid methylation that causes mast cells to degranulate