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Coordinated regulation of this transcription factor and its repressor suggests that this system may play a role in maintaining vascular homeostasis

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Furthermore, experimental evidence confirmed that the CoA pathway functions independently of GSH as a parallel mechanism conferring resistance to ferroptosis [137]

Gene expression analysis in peripheral memory T cells then revealed a clear PD-specific gene signature with transcriptomic markers for inflammation, oxidative stress, phosphorylation, autophagy of mitochondria, cholesterol metabolism, and chemokine signaling via CX3CR1, CCR5, and CCR1