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Taken together, these results suggest that Ssu72 induces adipogenesis and lipogenesis in white adipocytes by GSK3/-catenin axis under HFD conditions, contributing to adipose tissue expansion during diet-induced obesity

No established upper limit exists because excess b12 excretes through kidneys without causing harm

Furthermore, HFD-induced microbiota dysbiosis disrupted the intestinal barrier, increasing gut pathogenic bacteria and circulating endotoxin, which disequilibrated the local microenvironment and caused inflammation in the lung (Chakradhar, 2017)