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First, the PCA showed that the plasma samples from different experimental classes were not grouped separately (Data shown in Supplementary Figure S2)

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The balance of the different CRP isoforms, monomeric (mCRP) or native pentameric (nCRP) within the plaque determines the preponderance of a proinflammatory or anti-inflammatory effect, respectively (165)

Unlike previous approaches that typically focused on a single therapeu- tic function, this system is specifically engineered to simulta- neously target oxidative stress, infection, and impaired tissue regeneration in diabetic wounds