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Pairing glutathione with vitamin C, NAC, or alpha-lipoic acid can enhance its effects

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Such a sequence may share mechanistic features with the PRXII-GRX pathway shown in Figure 1, a principal difference being that H 2 O 2 would not react with a specific catalytic cysteine but rather in a more general way with free and reactive chloroplast protein cysteines

Finally, angiogenesis is regarded as a fundamental process in leukemogenesis and for chemosensitivity in AML (see Section 3.3), and soluble ferritin seems to influence endothelial cells and possibly also their dual AML-supporting function mediated by (i) increased bone marrow angiogenesis and (ii) increased AML-supporting effects mediated by vascular/endothelial stem cell niches