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R.RoosR.et al (2017)

Development of prodrugs The design of prodrugs or conjugates of rhamnetin that improve pharmacokinetic properties could enhance its stability, solubility, and tissue-specific targeting

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The initial trial mobile phase composed of ACN and water (5:95 v/v) containing 0.1% TFA at a flow rate of 1 ml/min resulted in early elution of NAC and poor response from placebo