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There are several factors that influence risk of toxicity due to NSAID use (Chen 2006

[246] showed that Nrf2 inhibition increased oxidative stress and aggravated hypertension in mice, whereas Nrf2 activation alleviated hypertension during Ang II infusion, highlighting its therapeutic relevance.Mitochondrial dysfunction, including impaired energy metabolism, increased mtROS, and mtDNA damage, amplifies ferroptosis and worsens endothelial injury [247, 248]

Viral protein Tat enhanced cellular expression of Nrf2 and its translocation into the nucleus

The authors believe these findings could be related to strong immune activation [48]