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Succinate is an electron donor to Complex II

28 , 25012508.e4 (2019)

doi: 10.1021/acs.jproteome.7b00352 249 MarySKulkarniMJMalakarDJoshiSRMehendaleSSGiriAP

As previously noted, the main way that DOX causes kidney damage is by triggering the oxidative stress cascade, which causes the natural antioxidant defense systems to be inhibited and ROS to be produced (Songbo et al