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Br J Pharmacol 136:659672 Rosenbrock H, Desch M, Kleiner O, Dorner-Ciossek C, Schmid B, Keller S, Schlecker C, Moschetti V, Goetz S, Liesenfeld KH, Fillon G, Giovannini R, Ramael S, Wunderlich G, Wind S (2018) Evaluation of pharmacokinetics and pharmacodynamics of BI 425809, a novel GlyT1 inhibitor: translational studies

In addition to overall obesity, specific manifestations of metabolic syndrome, such as insulin resistance, dyslipidemia, and visceral fat accumulation, may also play a particular role in the development of ED