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and lactate dehydrogenase A, LDHA) following TCR and costimulatory signals in a mTORC1-dependent manner ( N , which breaks down glucose to fuel TCA and OXPHOS to maintain basal energetic needs, increased glucose uptake in Teff is mostly converted to lactate or allocated to the proximal branch pathway to provide building blocks for synthesizing intermediates or macromolecules, although at the expense of low net ATP gain ( Induction of cytokine expression and effector function in Teffs is also a glucose-dependent process

Oncogenesis 12 , 16 (2023)

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Detailed animal studies or clinical trials are not published