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In vitro investigations have demonstrated that the aberrant activation of the MAPK signaling pathway in BRAF V600E-mutant TC can upregulate the production of DNMT1, thereby inducing hypermethylation of the TSHR promoter and leading to its transcriptional suppression [34, 35]

Individuals at higher risk include older adults with reduced stomach acid production, people with gastrointestinal conditions affecting absorption, strict vegans, and those taking medications like metformin or proton pump inhibitors

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