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A deficiency in B12 can lead to a a variety of conditions

10.1016/j.foodres.2014.01.051 38 LiuY.-R.XiaoB.-K.YangJ.-Y.GuoC.-H.ShenS.-J.TangZ.-S.et al (2015)

The one real exception so far is GHK-Cu in topical form, which the FDA moved onto the Category 1 list in a May 2026 update, so a pharmacy can compound it now