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[DOI] [PMC free article] [PubMed] [Google Scholar] 11.Gstraunthaler G, Holcomb T, Feifel E, Liu W, Spitaler N, Curthoys NP

If youve experienced severe allergy-like symptoms such as hives, difficulty breathing, low blood pressure, and severe diarrhea and your doctor diagnoses you with allergies you may actually have mast cell activation syndrome

The p K a of the histidine imidazole group is 6.5, and thus histidine behaves as hydrophobic residue at neutral pH, whereas it is protonated and behaves as a basic peptide in the slightly acidic endosomal milieu