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In the field of genetics, genome-wide association studies (GWAS) have highlighted a strong link between the LPA gene and PAD, indicating that therapeutic modulation of circulating Lp(a) could be effective for the PAD phenotype [137]

Spriestersbach, A., Kubicek, J., Schfer, F., Block, H

1,9,10 UNBALANCED METABOLISM IMPAIRS ENERGY PRODUCTION IN LC-FAOD Enzyme deficiencies in LC-FAOD result in an imbalance between anaplerosis and cataplerosis and can lead to the accumulation of toxic metabolites