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N Engl J Med 371 (20): 1867-76, 2014

Key Brain Regions The key anatomical sites of PT-141's action include: Medial preoptic area (MPOA) of the hypothalamus: A critical region for integrating sexual motivation and coordinating sexual behavior Paraventricular nucleus (PVN): Influences both descending autonomic pathways controlling genital arousal responses and ascending pathways to limbic regions Limbic system structures: Including amygdala and nucleus accumbens, which modulate dopaminergic and oxytocinergic systems Central vs