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Angiotensin IV is a derivative of the potent vasoconstrictor angiotensin II and has been shown to enhance acquisition, consolidation and recall of learning and memory in animal models when administered centrally or peripherally

Vitam Horm 119:241274 ( Elsevier ) Kuijpers TW, de Vries AC, van Leeuwen EM, Ermens AT, de Pont S, Smith DE, Wamelink MM, Mensenkamp AR, Nelen MR, Lango Allen H, Pals ST (2022) Megalobastic anemia, infantile leukemia, and immunodeficiency caused by a novel homozygous mutation in the DHFR gene

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This insight has guided Fc-engineering of IgG variants with improved pH-dependent FcRn binding, resulting in antibodies with extended plasma half-life in human FcRn transgenic mice, non-human primates (NHPs) as well as humans 10,23,24,25