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Our LC-MS and GC-MS platforms are optimized for both targeted quantification of known organic acids and untargeted screening for novel or unexpected metabolites

While our data suggest that production of NADPH by the TCA cycle is a key event in our proposed pathway, it is not yet clear how NADPH production corresponds to actual activity of the cyclegiven that metabolites can enter and exit the cycle at multiple points depending on nutritional conditionsnor how the cellular compartmentalization of NADPH production contributes to the transmission of the NADPH status to the ER

The analog retains full agonist activity at the IGF-1 receptor (IGF-1R) and has become the standard form of IGF-1 used in cell culture and preclinical research

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