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The carotenoids remained stable after digestion

The metabolic byproduct phosphoenolpyruvate (PEP) can act as an antioxidant to prevent ROS-mediated cell apoptosis (180)

Nrf2, the master regulator of antioxidant response, showed approximately 70% decreased expression and activity in CF cells compared to normal controls (Chen et al., 2008)

Specifically, it is thought that people with histamine intolerance dont produce enough diamine oxidase (DAO), the enzyme responsible for breaking down histamine in the intestines