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(1998) showed that -syn inhibits the activation of phospholipase D2 via PIP 2 , which hydrolyses glycerophosphocholines to produce phosphatidic acid and choline

Saudi Journal of Biomedical Research

This appears to be largely mediated through improvements in insulin sensitivity and weight loss, which reduce androgen excess and normalise hypothalamic-pituitary signalling

While its a good idea to discuss any amount of alcohol use with a healthcare provider when you are taking any medications, the FDA label for phentermine advises against combining phentermine and alcohol because of an increased risk of adverse reactions