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In: Handbook of Targeted Cancer Therapy

A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis

M., Elizondo-Luvano, J

Apart from exacerbating local inflammation, TNF- can activate the NF-KB and MAPK signaling pathways, increasing cellular susceptibility to oxidative stress and weakening GPX4 and other antioxidant enzymes, thereby promoting further accumulation of lipid peroxidation byproducts and markedly elevating ferroptosis risk (119)