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Several reports have also documented a dose- and duration-dependent association between chronic opioid treatment and new-onset depression [106]

Planta Med 65: 365-366

Finally, a promising line of research proposes a multifactorial approach, by developing a predictive algorithm based on familial/genetic factors, environmental adversity, early behavioral phenotype, biological markers [inflammatory cytokines, BDNF, markers of oxidative stress, and hypothalamicpituitaryadrenal (HPA) disturbance], and imaging data (7982)